Low-dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug-drug interaction study.

Br J Clin Pharmacol · 2026 · PMC13206195 · PMID 41398552

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did not reach statistical significanceno p-value reported

Furthermore, amitriptyline C last (LSM ratio 1.14, 95% CI: 0.99, 1.32, p = 0.058) and tramadol C max (LSM ratio 1.10, 95% CI: 0.99, 1.22, p = 0.064) increased after treatment with CBD but did not reach statistical significance.

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