An observational study on the effects of as-needed use of various antipsychotic drugs for agitation due to psychotic disorders.

Int Clin Psychopharmacol · 2026 · PMC13207436 · PMID 41609240

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0570

boldest claim

The sentences

showed a trendP = 0.057so close (0.05 < p ≤ 0.1)

Risperidone-OS showed a trend toward a lower hazard relative to asenapine-SL (hazard ratio 0.59; 95% CI: 0.34–1.02; P = 0.057).

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a nonsignificant trendno p-value reported

Using Cox proportional hazards models with asenapine as reference, quetiapine demonstrated a significantly lower hazard of achieving calming (hazard ratio 0.39), while risperidone showed a nonsignificant trend.

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