<i>Lactiplantibacillus plantarum</i> HY7718 Modulates Gut-Kidney Axis-Associated Inflammation, Gastrointestinal Dysfunction, and Gut Microbiota in Adenine-Induced Chronic Kidney Disease Mice.

Int J Mol Sci · 2026 · PMC13207469 · PMID 42196327

Europe PMC DOI

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an increasing trendno p-value reported

did not reach statistical significanceno p-value reported

As shown in Figure 1 A–C, the expression levels of Acta2 and Col1a1 were significantly elevated in the CKD group compared with those in the Normal group ( p < 0.001), whereas Tgf-β1 expression showed an increasing trend but did not reach statistical significance.

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a decreasing trendno p-value reported

However, Verrucomicrobiota showed a decreasing trend in the CKD group and a relative increase following HY7718 supplementation, whereas Pseudomonadota tended to increase in the CKD and AP groups.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

&lt;i&gt;Lactiplantibacillus plantarum&lt;/i&gt; HY7718 Modulates Gut-Kidney Axis-Associated Inflammation, Gastrointestinal Dysfunction, and Gut Microbiota in Adenine-Induced Chronic Kidney Disease Mice.

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<i>Lactiplantibacillus plantarum</i> HY7718 Modulates Gut-Kidney Axis-Associated Inflammation, Gastrointestinal Dysfunction, and Gut Microbiota in Adenine-Induced Chronic Kidney Disease Mice.