Interpretation of Pharmacometabolomics Results: Fingerprint of Drug Exposure or Confounder Effects? Insights from a Urinary Metabolomics Study with Voriconazole in Healthy Participants.

Int J Mol Sci · 2026 · PMC13208054 · PMID 42196446

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0900

boldest claim

The sentences

highly significantp = 0.001actually significant

The subsequent PERMANOVA confirmed very strong, highly significant metabolic shifts comparing predose and postdose metabolomics signatures with F = 20.665, R 2 = 0.408, p = 0.001 for visit 2 and with F = 16.084, R 2 = 0.349, p = 0.001 for visit 1, based on 999 permutations in both analysis cases.

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did not reach statistical significancep = 0.090so close (0.05 < p ≤ 0.1)

Oxypurinol excretion postdose was numerically increased, however, it did not reach statistical significance (raw p = 0.090). 2.1.3.

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