Effects of γ-Aminobutyric Acid (GABA) Supplementation on Symptoms, Quality of Life, Intestinal Permeability, Systemic Inflammation and Gut Microbiota in Patients with IBS-D: A Randomized, Double Blind, Placebo-Controlled, Crossover Pilot Study.

Nutrients · 2026 · PMC13209747 · PMID 42197028

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did not reach statistical significanceno p-value reported

A reduction in “Abdominal pain intensity”, “Number of days with abdominal distention”, and “Interference with daily life” were numerically greater with GABA- Melissa officinalis but did not reach statistical significance.

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partially significantno p-value reported

While these mechanisms may contribute to the improvement of clinical outcomes, the modest and only partially significant changes observed in this study warrant cautious interpretation and require confirmation in larger cohorts.

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