Synergistic Effects of Air Pollutants and Extreme Temperature on Asthma: A Narrative Review of Mechanisms and Evidence.

Toxics · 2026 · PMC13211335 · PMID 42198578

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did not reach statistical significanceno p-value reported

However, a 2025 meta-analysis encompassing 40 studies on adolescent asthma found that the pooled estimate for long-term SO 2 did not reach statistical significance (OR = 0.99), accompanied by 53.6% heterogeneity; small subgroup sample sizes, unit conversion discrepancies, and conflicting effect directions limit certainty, and an association cannot be excluded [ 69 ]. 3.4.2.

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