Comprehensive clinical and genetic architecture of familial amyotrophic lateral sclerosis in China: A 15-year cohort study with 302 families.

Neural Regen Res · 2026 · PMC13211834 · PMID 41673790

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did not reach statistical significanceno p-value reported

The L1CAM ( P = 2.3e−6) and ZNF512B ( P = 1.5e−5) genes were the second and third most enriched in rare variants, respectively, but the prevalences of such mutations did not reach statistical significance ( Figure 4 and Additional Table 14 ).

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