Desipramine treatment disrupts phagocytic and intracellular survival of <i>Brucella abortus</i> 544 in RAW 264.7 cells and promotes bacterial resistance with enhanced immune responses in ICR mice.

Although the reduction in liver bacterial load in DMI-treated mice did not reach statistical significance ( p = 0.14), the observed decrease of 0.82 log 10 CFU compared with the control group suggests a biologically relevant trend toward reduced bacterial persistence.

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Notably, DMI treatment in Brucella -infected mice significantly reduced bacterial loads in the spleen and showed a decreasing trend in the liver, along with enhanced Th1-associated immune responses.

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