Site-Specific Genomic Markers Associated with Outcomes of PD-1 Blockade in Gastric and Esophagogastric Junction Cancer: Analysis of Japan's C-CAT Registry.

In an exploratory analysis of the overall GC registry cohort ( n = 1801 with available OS data), ASXL1 showed a nonsignificant trend toward better OS from C-CAT registration (HR 0.71, 95% CI 0.50–1.01, P = 0.059) (Supplementary Fig.

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Although a prespecified sensitivity analysis broadening this to ASXL1 LoF variants did not reach statistical significance, point estimates remained in the same direction (HR < 1), consistent with limited power and variant-class heterogeneity rather than a reversal of effect.

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