Integrative imaging and transcriptomics implicate neutrophils in microvascular no-reflow after stroke.

A linear mixed-effects model on neutrophil counts (log-transformed fold-change from BL) revealed a highly significant effect of treatment: NeuDep reduced post-stroke neutrophil presence by ~ 3.2-fold relative to controls ( p < 0.0001).

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A model with Treatment, Age, and Sex as main effects showed a trend toward smaller infarcts with neutrophil depletion (β = − 8.0% hemisphere, p = 0.109), but this was not significant (model p = 0.096, R2 = 0.164).

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