Barely Significant
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Broadly neutralizing antibody-secreting CAR-T cells elicit Fc-mediated effector functions <i>in vitro</i> and suppress HIV in humanized mice.

Front Immunol · 2026 · PMC13214270 · PMID 42212149

Europe PMCDOI
1
hedged sentence
0.0913
closest p · 1.8× alpha
0.0913
boldest claim

The sentences

did not reach statistical significancep=0,0913so close (0.05 < p ≤ 0.1)
In comparison, treatment with CD4 CAR-T cells resulted in a 5.35-fold reduction in plasma viremia, which did not reach statistical significance (p=0,0913), while mice receiving GFP-3BNC117 cells showed a modest 2,48-fold reduction (p=0,7846), indicating partial viral inhibition mediated by secreted bNAbs in the absence of CAR-dependent targeting.

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