Epithelial NLRP3 drives silica-induced lung injury and fibrosis through IL-18 and pro-fibrotic neutrophil recruitment.

Morphometric analysis of trichrome-stained lung sections showed that mean linear intercept (MLI) was unchanged at day 14 (Supplementary Figure S4A, B), consistent with early-stage fibrosis, while alveolar septal thickness, significantly elevated in silica-exposed controls showed a trend toward reduction in alveolar epithelial Nlrp3 -deficient mice (Supplementary Figure S4C).

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