Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder Mutation <i>PSEN1</i> A431E.

Similarly, rs2242652 showed increased TERT expression in the GA genotype compared with the GG genotype, while the AA genotype—despite the smaller sample size—followed the same trend, with highly significant associations ( p ≈ 10 −6 –10 −5 ). 3.9.

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These genotype-level associations were nominally significant ( Table 7 ).

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