Neutrophil Extracellular Traps in Pancreatic Ductal Adenocarcinoma: A Vicious Cycle in the Tumor Microenvironment and Targeted Interventions.

Although this difference did not reach statistical significance, the observed trend supports targeting autophagy to suppress NETs and potentially reduce thrombotic risk 185 . 5.2.2 Targeting NET-Derived HMGB1 EMT is recognized as a key mechanism through which NETs promote tumor metastasis and invasion 41 .

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