Characterization of the tumor microenvironment in locally advanced gastric cancer and identification of spatially predictive biomarkers associated with beneficial neoadjuvant immunochemotherapy.

Front Immunol · 2026 · PMC13215860 · PMID 42220510

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significanceP = 0.06so close (0.05 < p ≤ 0.1)

a strong trendno p-value reported

A high CD8 + T cell signature score was associated with significantly improved OS (P = 0.06, borderline significance) and a strong trend toward better PFS ( Figures 5C, D ).

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a notable trendno p-value reported

Conversely, a high Treg signature score correlated with a notable trend toward shorter PFS, although no significant difference was observed for OS ( Figures 5E, F ).

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