Prognostic impact of p53 and HER2 immunohistochemistry profiles in colorectal carcinoma.

Kaplan–Meier analysis and Cox regression censored at 5 years showed no significant impact of p53 or HER2 on OS, except for a borderline non-significant adverse effect of the p53 null phenotype (restricted mean OS = 3.40 vs. 3.91 years, p = 0.053; HR = 1.59, 95% CIs 0.99–2.54, p = 0.055) ( Figure 6A ), and significant negative effect of the p53 null phenotype in multivariable age-adjusted Cox regression (HR = 1.61, 95% CIs 1.01–2.58, p = 0.047) ( Figure 6B ).

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