Neuro-Behavioral Improvement and Mechanistic Pathways of Bone Marrow-Derived Mesenchymal Stem Cells and Exosomes in Experimental Multiple Sclerosis: A Systematic Review and Meta-analysis.

Cell Mol Neurobiol · 2026 · PMC13216409 · PMID 41998337

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)

Our meta-analysis indicated that MSC therapy was associated with an increase in serum IL-10 levels in MS models; however, this elevation did not reach statistical significance (SMD = 7.36, 95% CI: −0.58 to 15.29, I 2 = 99.73%, P = 0.07, Fig. 6 A) (Hao et al. 2016 , Li et al. 2019 , Yu et al. 2016 , Ryu et al. 2013 , Guo et al. 2013 , Nasri et al. 2018 ).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.