Complement C5 inhibition in generalized myasthenia gravis is associated with improved survival and increased cardiovascular risk.

Front Immunol · 2026 · PMC13216512 · PMID 42220523

Europe PMC DOI

hedged sentences

0.0650

closest p · 1.3× alpha

0.0650

boldest claim

The sentences

a trend toward significancep=0.065so close (0.05 < p ≤ 0.1)

For the composite endpoint of MACE ( Figure 3D ), C5-treated patients exhibited lower event-free survival (91.4% vs 93.7%), with a trend toward significance (p=0.065), although the HR did not reach statistical significance (HR 1.355; p=0.181).

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did not reach statistical significanceno p-value reported

Rates of acute myocardial infarction were numerically higher (2.0% vs 1.0%; OR 2.021, p=0.054) but did not reach statistical significance.

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