Gene- and subtype-dependent prognostic impact of ras pathway mutations in acute myeloid leukemia: a cohort study of 2,500 patients.

Blood Cancer J · 2026 · PMC13216541 · PMID 42204149

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0.0620

closest p · 1.2× alpha

0.0620

boldest claim

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showed a trendp = 0.062so close (0.05 < p ≤ 0.1)

PTPN11 mutations were associated with inferior EFS and showed a trend toward worse OS (5-year OS: 54.6% [95% CI, 45.9–65.0%] vs. 60.5% [95% CI, 57.9–63.2%], p = 0.062; 5-year EFS: 45.3% [95% CI, 36.9–55.6%] vs. 49.9% [95% CI, 47.3–52.6%], p = 0.017; Fig. 1E, F ).

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