highly significantp < 0.001
Adjusted model (controlled for age, BMI, smoking, GOLD stage): CAT score → BODE index: β = 0.122 (95% CI: 0.098-0.146), p < 0.001; adjusted R2 = 0.720 Interpretation: The adjusted association remained highly significant (p < 0.001) and was not materially different from the unadjusted correlation (Δβ = 0.004, or 0.6% change), suggesting minimal confounding by age, BMI, smoking status, or disease severity classification.