Recurrent Copy Number Variants and Psychiatric Outcomes in the Context of Polygenic Scores.

We also found no significant interaction on the log-odds scale between PGSs and individual rCNVs, except for the 16p13.11 duplication and ADHD-PGS (β = −0.51; 95% CI, −0.86 to −0.16; P = .006), although, there was a significant trend for negative interaction coefficients (27 of 39; P = .01 in a binomial test) (eTables 11 and 12 in Supplement 2 and eTables 13 and 14 in Supplement 1 ).

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