Portal-Venous Hypothermic Oxygenated Perfusion for Liver Transplant: A Randomized Clinical Trial.

7 , 13 , 32 However, reductions in biliary complications did not reach statistical significance, possibly reflecting the persistent vulnerability of the biliary epithelium despite optimized preservation and the need for viability assessment. 35 Mechanistically, HOPE was previously associated with reduced ischemia reperfusion injury by stabilizing mitochondrial respiration, metabolizing accumulated succinate, and reducing oxidative stress during subsequent reperfusion at transplant. 36 Global adoption of machine liver perfusion remains limited by logistical and cost concerns.

also in 111,027 other papers