A LASSO-based nomogram for predicting acute bilirubin encephalopathy in newborns with severe hyperbilirubinemia.

Front Pediatr · 2026 · PMC13219266 · PMID 42220995

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did not reach statistical significanceno p-value reported

Breastfeeding (OR = 0.454, 95%CI: 0.084–1.628, P = 0.279) and abnormal hemoglobin (OR = 1.821, 95%CI: 0.654–4.811, P = 0.235) were retained by LASSO but did not reach statistical significance in the multivariate analysis.

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marginally non-significantno p-value reported

This finding is consistent with the rationale for LASSO-based variable selection, where predictors may be retained due to regularization stability even when marginally non-significant in subsequent logistic regression, particularly in small samples.

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