Loss of Gαq reshapes fibroblast traits and drives tumor-stroma remodeling in oral cancer progression.

Although variability was observed between sample pairs and the differences did not reach statistical significance, we found a moderate but consistent downregulation of Gαq expression in the CAFs compared to NFs, which correlated with an upregulated PDGFR expression in such tumor fibroblasts (n of 6, Fig. 7G ).

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