Construction and evaluation of an engineered autonomously lysing Salmonella system coupled with self-assembled nanoparticles as a vaccine platform for antigen delivery.

Additionally, although the pathological score in the χ9241 (pYA3342- tse1 - pspA ) group was elevated relative to that in the χ9241 (pYA3342- tse1 - pspA -E2p) group, the difference did not reach statistical significance (Fig. 5 A).

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Among these, the bacterial burden of χ9241 (pYA3341- tse1 ) in the tissues showed a decreasing trend after day 3, whereas χ9241 (pYA3332- tse1 ) and χ9241 (pYA3342- tse1 ) maintained relatively stable colonization levels over the subsequent 11 days (Fig. 3 E and G).

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