Evolutionary refinement of the ZIKV 5' UTR dictates a trade-off between RNA stability and promoter accessibility.

Interestingly, while the results did not reach statistical significance, we observed that the half-lives appeared to correlate with the ΔG predictions for each of the variants, with SLA Alt exhibiting the longest half-life, followed by SLA Anc , SLA Int , and SLA Con (Table 1 ).

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