CLEC2B-KLRB1 axis acts as an immune checkpoint, governing the exhaustion of CD8<sup>+</sup> T cells and their resistance to immune checkpoint blockade.

J Immunother Cancer · 2026 · PMC13223962 · PMID 42208981

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showed a trendno p-value reported

Among highly infiltrated samples, the median proportion of Tex in MSS CRC showed a trend towards being higher, although not statistically significant (Extended Data online supplemental figure 2j).

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CLEC2B-KLRB1 axis acts as an immune checkpoint, governing the exhaustion of CD8&lt;sup&gt;+&lt;/sup&gt; T cells and their resistance to immune checkpoint blockade.

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CLEC2B-KLRB1 axis acts as an immune checkpoint, governing the exhaustion of CD8<sup>+</sup> T cells and their resistance to immune checkpoint blockade.