Longer durations of piperacillin/tazobactam treatment cause more prolonged alteration of colonization resistance in mice.

Results Longer durations of piperacillin/tazobactam treatment cause greater alteration of in vitro colonization resistance when challenge occurs 6 days after the last treatment dose Fig 1 shows the impact of different piperacillin/tazobactam treatment durations on in vitro colonization resistance (data and analysis shown in S1 Table ) For Kp VA367, cecal contents of mice in the 6-, and 10-day treatment groups had significant growth in comparison to saline controls (P = 0.005), cecal contents of mice in the 3-day treatment group had increased growth that did not reach statistical significance (P = 0.053), and cecal contents of mice in the 1-day treatment group did not have significant growth in comparison to saline controls (P = 0.63).

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