Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.

Front Genet · 2026 · PMC13225775 · PMID 42232515

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

nominally significantP < 1 × 10 −5actually significant

In addition, although the PheWAS did not reveal any signals for serious adverse reactions after strict correction, EP300 and P2RY14 show nominally significant associations with traits related to femur shaft bone and caudate nucleus (P < 1 × 10 −5 ), suggesting that their biological effects may not be limited to the intestine.

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