N-acetylcysteine modulates neutrophil-driven immune and metabolic pathways in steatotic liver ischemia-reperfusion injury.

Front Immunol · 2026 · PMC13226007 · PMID 42238593

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HFD IRI livers showed a trend toward reduced abundance of phosphatidylcholines, a membrane-stabilizing component, relative to ND IRI, consistent with NAFLD/MAFLD-associated phospholipid dysregulation that sensitizes hepatocytes to metabolic stress ( 27 , 30 , 31 ).

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