Phenotypic Response Surfaces-Guided Optimization (PRS-OPT) of Propolis-Metformin-Regorafenib Combination Therapy for MASLD-Associated Hepatocellular Carcinoma.

Oncol Res · 2026 · PMC13227599 · PMID 42238013

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showed a trendno p-value reported

PMR did not reduce lipid accumulation in PLC/PRF/5 and showed a trend toward increased lipid signal under FA, whereas metformin alone (and within PMR) reduced lipid signal in HepG2.

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