Nineteen participants infected during the 2023 autochthonous dengue outbreak in Rome (10 PLWH and 9 HIV-negative individuals) were assessed for interferon gamma (IFN-γ)-releasing cells in peripheral blood mononuclear cells (PBMCs) using an IFN-γ -ELISpot assay following stimulation with peptide pools.When examining both the overall cumulative ELISpot responses, calculated as the sum of spot-forming units (SFU) across all antigens or the binary responder status to each DENV antigen, HIV-negative individuals showed higher and broader cumulative responses than PLWH, but differences did not reach statistical significance.
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Dengue-specific T-cell memory following natural infection: a comparative analysis between people living with HIV and HIV-negative individuals.
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