Efficacy and heterogeneity: an exclusive human milk diet for necrotizing enterocolitis prevention in very preterm infants-a systematic review and meta-analysis of 11 studies.

Front Nutr · 2026 · PMC13229633 · PMID 42245555

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0.1600

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0.1600

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did not reach statistical significancep = 0.16not close (p > 0.1)

EHMD was associated with a 39% reduction in definite NEC that did not reach statistical significance [Risk Ratio (RR) = 0.61, 95% CI: 0.30–1.22, p = 0.16], though heterogeneity was high ( I 2 = 89%).

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