At the family level, early disease mice exhibited the largest deviations from naïve controls, with decreased Lachnospiraceae and increased Prevotellaceae , Rikenellaceae , and Muribaculaceae , while during pre-disease, mice already showed a trend toward lower Lachnospiraceae and higher Lactobacillaceae ( Figure 6B ).
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Microbiota-specific serum IgG links gut and joints through immune-endothelial crosstalk in arthritis.
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