Parathyroid hormone enhances appetite and fails to reduce adiposity in ob/ob mice.

Under these conditions, PTH-treated ob/ob mice showed only a slight trend toward reduced body weight compared to vehicle-treated counterparts (Fig. 4 A), with no changes in fasting serum glucose or insulin levels (Fig. 4 , B and C).

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We found that ob/ob mice were already hyperphagic compared to their littermates, and PTH treatment showed a trend toward further increasing food intake in ob/ob mice (Fig. 3 G).

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