In nonresponding OVA-B16 tumors, tumor size showed a weak positive trend with NF-κB activity in the BM ( r = 0.26), although this did not reach statistical significance, whereas responding OVA-MC38 tumors exhibited a weak inverse relationship ( r = −0.18) (Fig. 2 G and E ).
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Noninvasive in vivo imaging of NF-κB activation predicts immunotherapy response in solid tumors.
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