Effect of low-level laser therapy versus calcium hydroxide intra-canal medication on postoperative pain and inflammatory mediator reduction in symptomatic apical periodontitis: a randomized clinical trial.

Tooth type showed a marginally significant difference ( P = 0.049), however, prior studies found it unrelated to postoperative pain, with only preoperative symptoms being predictive [ 2 ].

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In the intervention (LLLT) group, the reduction from a baseline of 111 ± 61.6 ng/L (PS-1) to 95.7 ± 25 ng/L(PS-2) did not reach statistical significance ( p = 0.064).In contrast, the control group demonstrated a statistically significant decrease in IL-8 concentrations, falling from 86.7 ± 20.5 ng/L (PS-1) to 61.9 ± 33.5 ng/L (PS-2) over the same period ( p = 0.044) (Table 9 ) (Fig. 12 ).

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