CCK-8 assays revealed that Dextran-CTX-GLA-EuK exhibited marginally higher cytotoxic effects than the parent CTX and other conjugates, although these differences failed to reach statistical significance after 72 h of incubation with PSMA-overexpressing cells ( Table 1 ).
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A PSMA-targeted dextran-based conjugate eradicates PSMA-overexpressing prostate tumors while abolishing cabazitaxel toxicity.
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