Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brain

Robust and highly significant associations were observed for all four markers, including pTau ( ρ = 0.73, p < 0.0001), microglia ( ρ = 0.76, p < 0.0001), Aβ ( ρ = 0.61, p < 0.0001), and myelin ( ρ = 0.94, p < 0.0001).

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Predicted A β density showed a modest inverse trend with MMSE in WM ( ρ = −0.48), but this association did not reach statistical significance, and no corresponding trend was observed in the hippocampus.

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