Primary Cilium Forces Neuroendocrine Shift in Prostate Cancer through YAP1 Repression and Reduced Mitochondrial Activity.

Consistently, immunoblot analysis showed a marked reduction in the expression of mitochondrial complexes I, II and IV, with a decreasing trend also observed for complexes III and V, in enzalutamide-treated LNCaP cells (Figure 6 H), supporting a disruption of mitochondrial oxidative phosphorylation.

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However, only GLI1 mRNA expression was significantly induced in Nx and showed a trend in Hx 1%, while IFT20 mRNA expression remained unchanged (Figure 2 E - Figure S4 C).

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