Combined patch-clamp electrophysiology and single-cell genomic analysis reveal spiking tumor cells at the neocortical glioblastoma interface in humans.

Neuro Oncol · 2026 · PMC13232509 · PMID 41857760

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In terms of ion channel signaling, aAP GBCs showed a trend of higher expression of Na V channel SCN3A compared to no-aAP GBCs, supporting their difference in aAP generation capability ( Supplementary Figure S13G ).

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