Three-dimensional quantitative morphometric analysis (QMA) allows for reproducible and sensitive assessment of bone and joint in a preclinical mouse model of osteoarthritis.

Although the differences did not reach statistical significance, the mean value of Ct.Po in the medial tibia of the OA8 group was approximately 3 times higher in joints compared to those without ( Table 5 ).

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This suggests a notable trend toward more porous cortical bone, aligning with recent findings reported by Liu et al. 47 Furthermore, the strong correlation observed within the OA8 group between the novel osteophyte parameter, k , and histological osteophyte scores underscores its potential as a helpful marker for osteophyte detection and quantification in future research.

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