The Efficacy of Nicotinamide in Maintaining Mean Deviation in Glaucoma: A Systematic Review.

Cureus · 2026 · PMC13233098 · PMID 42244899

Europe PMC DOI

hedged sentence

0.6300

closest p · 12.6× alpha

0.6300

boldest claim

The sentences

did not reach statistical significancep = 0.63not close (p > 0.1)

In Hui et al.’s RCT, mean MD did improve by +0.10 dB compared to placebo across the 24-week trial but did not reach statistical significance (95% CI -0.33 to +0.53 dB, p = 0.63) [ 15 ].

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