GLIS3 drives epithelial-mesenchymal transition and cancer stem-like traits in stomach adenocarcinoma via TGFBR3-Hedgehog signaling.

Front Oncol · 2026 · PMC13233252 · PMID 42255230

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showed a trendno p-value reported

Consistently, in HGC-27 cells, RT-qPCR analysis of endogenous Hedgehog target genes showed that either TGFBR3 silencing or vismodegib alone reduced transcript levels to 0.5–0.6 of control, whereas the si-TGFBR3 + vismodegib group showed a trend toward the lowest mean expression ( Supplementary Figure 1G ).

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