High-flow nasal cannula versus noninvasive ventilation in stabilized hypercapnic exacerbation: a physiological crossover trial.

Ann Intensive Care · 2026 · PMC13233617 · PMID 42256212

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[ 26 ] reported that in hypercapnic COPD patients with mild to moderate exacerbation, HFNC at 30 L.min −1 reduced inspiratory effort to a level comparable to NIV, while higher flows showed a trend toward increasing the inspiratory effort in some patients.

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