Clinical and vaginal microbiota effects of oral Lactobacillus crispatus M247 combined with vaginal laser therapy in menopausal women with atrophic vulvovaginitis: a prospective, randomized and controlled study.

Analysis of variance based on the longitudinal mixed-effects model revealed a highly significant main effect of treatment group ( p = 0.00004), whereas neither the main effect of time ( p = 0.17076) nor the group × time interaction ( p = 0.89380) reached statistical significance (Supplementary File 2 ).

also in 132,142 other papers

Mixed-effects model analysis supported these findings, demonstrating a highly significant main effect of time on vaginal burning severity ( p < 0.0001) and a significant main effect of treatment group ( p = 0.02448), while the group × time interaction did not reach statistical significance ( p = 0.33970), indicating parallel temporal trends between the two treatment arms (Supplementary File 17 ).

also in 111,027 other papers