A live biohybrid bacterial therapy based on engineered Serratia marcescens.

Additionally, the SM strain and its modified derivatives showed a trend toward lower residual rates in normal tissues, particularly the heart and liver, compared to ECN and VNP20009 , although these differences were not statistically significant (Fig. 6f ).

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Although caspase-3 and cleaved caspase-3 show a decreasing trend, suggesting that caspase-dependent apoptosis may not be the dominant cell death mechanism, the overall impact of apoptosis should not be excluded (Fig. 7d ).

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