Rational design of a modular mRNA vaccine platform for rapid adaptation to SARS-CoV-2 variants.

Sci Rep · 2026 · PMC13234338 · PMID 42236761

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highly significantno p-value reported

Direct comparison of the IgG2a to IgG1 titers demonstrated a highly significant increase in the WT and XBB1.5 S-specific IgG2a/IgG1 ratios for TP2A (mean endpoint titers WT S-protein: 1:192.000 (IgG2a), 1:30.400 (IgG1), IgG2a/IgG1 ratio = 6,32 ( p < 0.0001); mean endpoint titer XBB1.5 S-protein: 1:164.000 (IgG2a), 1:9.225 (IgG1), IgG2a/IgG1 ratio = 17,78 ( p < 0.0001)).

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did not reach statistical significanceno p-value reported

In contrast, differences in the IgG2a to IgG1 ratio for XBB-S6P did not reach statistical significance (data not shown).

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