Synaptic alterations are preceding the axonal loss in optic atrophy of Wolfram syndrome mouse model.

Front Neurosci · 2026 · PMC13236678 · PMID 42255937

Europe PMC DOI

hedged sentences

0.0832

closest p · 1.7× alpha

0.0832

boldest claim

The sentences

a trend that approached significancep = 0.0832so close (0.05 < p ≤ 0.1)

Quantification of NF200 counts for the 7-month group yielded an average of 315,838 ± 28,571 per mm 2 in WT compared to 205,618 ± 46,408 per mm 2 in Wfs1 knockout mice, a trend that approached significance ( p = 0.0832; Figure 7D ).

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did not reach statistical significanceno p-value reported

However, quantification of relative mean intensity showed a reduction in Wfs1 KO mice compared to WT mice, but did not reach statistical significance (Data not shown).

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