Calpain inhibition by calpeptin modulates adipocyte lipid metabolism and secretome-mediated inflammatory crosstalk with hepatocytes.

However, the individual pathways in the metabolite set enrichment analyses did not reach statistical significance and, at this stage, should be interpreted as exploratory. 18:2n-6 metabolism, glycosylphosphatidylinositol-anchor biosynthesis, 18:3n-3 metabolism, and 20:4n-6 metabolism ranked highest in the pathway enrichment/pathway topology analysis of EVs from 25 μM calpeptin-treated adipocytes compared to control EVs (Supplementary Fig.

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